TESKEY GC, RACINE RJ
BRAIN RESEARCH
624: (1-2) 11-18 OCT 8 1993

Abstract

Changes in neuronal excitability that persist after seizures may play a key role in epilepsy. In this study, extracellular single unit recording techniques were used to investigate the changes in cell discharge patterns that result from kindling in vivo. The spontaneous activity of piriform and perirhinal cortical units in chronically implanted adult rats was recorded before, during and after kindling the amygdala. We observed that kindling-induced seizures resulted in a prolonged and dramatic increase in the rate of spontaneous background neuronal discharge in both the piriform and perirhinal regions.

Author Keywords

KINDLING, EPILEPSY, AMYGDALA, PIRIFORM CORTEX, PERIRHINAL CORTEX, RAT, NEURAL PLASTICITY, UNIT

KeyWords Plus

PAIRED-PULSE DEPRESSION, DENTATE GYRUS, EPILEPTIFORM ACTIVITY, HIPPOCAMPAL SLICES, PYRIFORM CORTEX, STIMULATION, POTENTIATION, GENERATION, SEIZURE

Addresses

TESKEY GC, UNIV CALGARY, DEPT PSYCHOL, 2500 UNIV DR NW, CALGARY T2N 1N4, ALBERTA, CANADA.
MCMASTER UNIV, DEPT PSYCHOL, HAMILTON L8S 4L8, ONTARIO, CANADA.

Publisher

ELSEVIER SCIENCE BV, AMSTERDAM

IDS Number

MA059

ISSN

0006-8993