University of Calgary

Richard Dyck

  • Professor
  • +1 (403) 220-4206
  • +1 (403) 220-5093


Our mission is to uncover behavioural, cellular and synaptic mechanisms that are responsible for mediating experience- and activity-dependent changes to the neural circuitry of the cerebral cortex. We are interested in understanding changes that occur normally, in the developing and adult cortex, as well as when things go awry. We apply multidisciplinary approaches, including molecular, genetic, anatomical, and behavioural assays in a model nervous system - the mouse's - to reveal mechanisms of plasticity in the cerebral cortex.

Research Support

Natural Sciences and Engineering Research Council of Canada

Recent Publications

McAllister BBPochakom AFu S, Dyck RH (2020) Effects of social defeat stress and fluoxetine treatment on neurogenesis and behaviour in mice that lack zinc transporter 3 (ZnT3) and vesicular zinc, Hippocampusdoi: 10.1002/hipo.23185.

McAllister BBBihelek N, Mychasiuk R, Dyck RH (2020) Brain-derived neurotrophic factor and TrkB levels in mice that lack vesicular zinc: Effects of age and sex, Neuroscience, 425:90-100. doi: 10.1016/j.neuroscience.2019.11.009. 

McAllister BBThackray SEde la Orta BKGGosse ETak PChipak CRehal SValverde Rascon A, Dyck RH (2020) Effects of enriched housing on the neuronal morphology of mice that lack zinc transporter 3 (ZnT3) and vesicular zinc, Behavioural Brain Research, 379:1-9. doi: 10.1016/j.bbr.2019.112336

Moshirpour M,  Nakashima AS, Sehn N, Smith VM,  Thackray SE, Dyck RH, Antle MA (2020, in press) Examination of zinc in the circadian system, NeuroscienceBIORXIV/2019/790352.

McAllister BB, Wright DK, Wortman RC, Shultz SR, Dyck RH (2018) Elimination of vesicular zinc alters the behavioural and neuroanatomical effects of social defeat stress in mice, Neurobiology of Stress, 9:199-213.

Wu H-P, Dyck RH (2018) Signaling by synaptic zinc is required for whisker-mediated, fine texture discrimination, Neuroscience, 369:242-247.

Kiryanova V, Smith VM, Antle MC, Dyck RH (2018) Behavior of adult 5-HT1a receptor knockout mice exposed to stress during development, Neuroscience, 371:16-28.

Kiryanova VMeunier SJ, Dyck RH (2017) Behavioural outcomes of female offspring following maternal stress and perinatal fluoxetine exposure, Behavioural Brain Research, 331:84-91.

McAllister BB, Dyck RH (2017) A new role for zinc in the brain, eLife 6:e31816 DOI: 10.7554/eLife.31816

McAllister BB, Dyck RH (2017) Zinc transporter 3 (ZnT3) and vesicular zinc in central nervous system function, Neuroscience & Biobehavioral Reviews, 80:329-350.

Thackray SE, McAllister BB, Dyck RH (2017) Behavioral characterization of female zinc transporter 3 (ZnT3) knockout mice, Behavioural Brain Research, 321:36-49.

Dennis DJ, Wilkinson G, Li S, Dixit R, Adnani L, Balakrishnan A, Han S, Kovach C, Gruenig N, Kurrasch DM, Dyck RH, Schuurmans C (2017) Neurog2 and Ascl1 together regulate a postmitotic derepression circuit to govern laminar fate specification in the murine neocortex. Proceedings of the National Academy of Sciences, 114(25): E4934-E4943.

Kiryanova V, Smith V, Dyck RH, Antle MA (2017) Circadian behavior of adult mice exposed to stress and fluoxetine during development. Psychopharmacology, 234(5): 793-804. 

Kiryanova VMeunier SJ, Vecchiarelli H, Hill MN, Dyck RH (2016) The effects of stress and perinatal fluoxetine exposure on behavioural outcomes of adult male offspring. Neuroscience, 320:281-296.


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